Extensionsdelen har designats för att ge ytterligare information som kompletterar den primära kohorten av 31 patienter. Nio av dessa patienter behandlas

Antikroppen CAN04 tolererades väl och 6 mg/kg är en säker dosEffekt på biomarkörer och 5 av 13 utvärderbara patienter uppnådde stabil

Publicerad: 2020-10-02 (Cision) Cantargia AB: Cantargia rapporterar att första patienten behandlats med CAN04 i en fas I studie i USA som studerar kombination med pembrolizumab Dessa data visar att genom att addera CAN04 är responsfrekvensen högre än historiska data där enbart dessa standardcellgifter använts. 4 av 7 utvärderbara patienter med metastaserande bukspottskörtelcancer (pancreatic cancer, PDAC) och 2 av 3 patienter med metastaserande icke-småcellig lungcancer (non-small cell lung cancer, NSCLC), inklusive 1 patient med komplett respons (complete CAN04 fungerar genom en dubbelverkande immunonkologisk mekanism. Dels stimuleras immunceller att avdöda tumörceller, dels motverkas tumörinflammationen genom att IL-1 signalering blockeras. De sjukdomar som kommer studeras är icke-småcellig lungcancer, bukspottkörtelcancer, tarmcancer samt trippelnegativ bröstcancer. This study will consider the safety and effectiveness of a study drug, CAN04, in combination with pembrolizumab, in the treatment of incurable or metastatic non-small-cell lung cancer, head and neck squamous cell carcinoma, urothelial cancer, or malignant melanoma. CAN04 is a first-in-class fully humanized monoclonal antibody targeting IL1RAP blocking IL-1 alpha and beta signaling and triggering antibody dependent cellular cytotoxicity.

The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of interleukin-1 (IL-1) signaling. CAN04 increased the anti-tumor effects in mice when combined with different registered platinum-based therapies (cisplatin, carboplatin or oxaliplatin) in either a patient-derived NSCLC model or CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in phase IIa clinical development in Europe. The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung cancer and pancreatic cancer. The study is focused on combination therapies, but also includes a monotherapy arm. Positive interim data from the combination therapies were presented in December 2019. The patients will start therapy at 5 mg/kg CAN04 and can receive treatment until disease progression.

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Av Cantargia. 10 feb 2021. Cantargia utvecklar antikroppsbaserade läkemedel riktade mot IL1RAP. Antikroppen CAN04 binder IL1RAP med hög affinitet och dess antitumör-aktivitet innefattar både stimulering av immunceller för att eliminera cancerceller liksom blockad av interleukin 1 signalering.

Include playlist. An error occurred while retrieving sharing information. Please CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP). The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment.
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Preklinisk utveckling. Cantargia har visat att IL1RAP uttrycks på tumörer från flera olika cancerformer och att CAN04 binder starkt till CAN04. Pancreatic cancer. Non-small cell lung cancer.

Forskningsbolaget Cantargia har gjort viktiga framsteg under hösten och är nu igång med en klinisk studie på sin läkemedelskandidat CAN04. Projektet har fått oväntad draghjälp av en studie från Novartis som indikerar att den mekanism CAN04 använder för att bekämpa cancer kan fungera.
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STOCKHOLM, July 4, 2019 /PRNewswire/ -- Cantargia´s antibody CAN04 (nidanilimab) is investigated in an open label three-armed phase IIa clinical trial, CANFOUR. Here, CAN04 is examined as monotherapy or in chemotherapy combinations in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC).

Edison menar att Can04 är ”tydligt differentierad” från Novartis kandidat. 1 dag sedan · Thereby, CAN04 can counteract the contribution of the IL-1 system to the immune suppressive tumor microenvironment and development of resistance to chemotherapy. CAN04 is investigated in two CAN04 combined with different chemotherapy regimens resulted in additive or synergistic antitumor effects and the results were presented at the 2020 Annual Meeting of the American Association for CAN04 Framsteg i utvecklingsarbetet: dosnivå vald CAN04 är i klinisk fas IIa-utveckling för icke-småcellig lungcancer (NSCLC) och bukspottkörtelcancer (PDAC) i CANFOUR-studien.

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Studien är designad att komplettera det pågående kliniska programmet och därmed bredda utvecklingen av CAN04. Fas Ib-studien planeras

Pancreatic cancer. Non-small cell lung cancer. Solid tumors UNIQUE IMMUNOTHERAPY ANTIBODY CAN04 IN PHASE IIA Antikroppen CAN04 binder IL1RAP med hög affinitet och fungerar både genom s.k.